공학DB
한국과학기술원 Biomicrofluidics Lab
실험실 소개 이미지
실험실 정보안내
지도교수 전성윤
전공분류 유체역학(Fluid Mechanics)
주소 대전 유성구 대학로 291(N7) 3203
전화
홈페이지 http://jeon.kaist.ac.kr/
실험실소개

Microfluidics enable applications of biophysical and biochemical stimuli to utilize engineering principles to better elucidate the nature of biological response in question.

연구분야

​Microfluidic platforms for biological application

 

Microfluidic systems have major advantages in studying biological phenomenon since they can mimic aspects of the 3D in vivo situation in a controlled environment while simultaneously providing in situ imaging capabilities for visualization and enabling cell-cell and cell-matrix interaction quantifications. Despite supporting experimental evidence showing the importance of complex microenvironment, none of the previously reported in vitro systems has reproduced the specific cross-talk among several cell types in a complex pathophysiological microenvironment such as cancer or atherosclerosis model. Moreover, microfluidics allow parametric study of multiple factors in controlled and repeatable conditions. In Biomicrofluidics Lab, we will develop a microfluidic assay and use it to study different disease models including cancer metastasis and evolution of atherosclerosis. The platform will allow organ-specific mimetic to better clarify the mutual interactions between different cell populations in a well-defined microenvironment, in order to develop highly focused and more effective therapies.

연구성과
C.Lee*, S.Kim*, H.Hugonnet, M.Lee, W.Park, J.S.Jeon+, YK.Park+
Label-free three-dimensional observations and quantitative characterization of on-chip vasculogenesis using optical diffraction tomography
bioRxiv, 2020 , ,Vol. 0No. 0 ,pp. 0 ~ 0(SCIE, 0:0.0

N.Yoon, S.Kim, H.K.Sung, T.Q.Dang, J.S.Jeon, G.Sweeney+
Use of 2-dimensional cell monolayers and 3-dimensional microvascular networks on microfluidic devices shows that iron increases transendothelial adiponectin flux via inducing ROS production
Biochimica et Biophysica Acta - Gen, 2020 , ,Vol. 0No. 0 ,pp. 0 ~ 0(SCIE, 0:0.0

J.Park*, N.Oh*, H.Nam, J.Park, S.Kim, J.S.Jeon+, M.Yang+
Efficient Capture and Raman Analysis of Circulating Tumor Cells by Nano-Undulated AgNPs-rGO Composite SERS Substrates
Sensors, 2020 , ,Vol. 11No. 0 ,pp. 5089 ~ 0(SCIE, 0:0.0