Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles
A. D. Dinsmore(Harvard University, Cambridge)
USA | Science 01 Nov 2002
2002.11.01 | 바로가기
Cited by 2160
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Science 01 Nov 2002: Vol. 298, Issue 5595, pp. 1006-1009
A. D. Dinsmore1,*,†, Ming F. Hsu1, M. G. Nikolaides1,‡, Manuel Marquez2, A. R. Bausch1,*,‡, D. A. Weitz1,*
1 Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA.
2 Los Alamos National Laboratory, Chemistry Division, Los Alamos, NM 87545, USA, and The Nanotechnology Lab, Kraft Foods R&D, 801 Waukegan Road, Glenview, IL 60025, USA.
We present an approach to fabricate solid capsules with precise control of size, permeability, mechanical strength, and compatibility. The capsules are fabricated by the self-assembly of colloidal particles onto the interface of emulsion droplets. After the particles are locked together to form elastic shells, the emulsion droplets are transferred to a fresh continuous-phase fluid that is the same as that inside the droplets. The resultant structures, which we call “colloidosomes,” are hollow, elastic shells whose permeability and elasticity can be precisely controlled. The generality and robustness of these structures and their potential for cellular immunoisolation are demonstrated by the use of a variety of solvents, particles, and contents