Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping
Wonryung Lee(The University of Tokyo)
United States | Science Advanced
2018-10-03 | 바로가기
Cited by 43
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03 October 2018
Wonryung Lee1, Shingo Kobayashi2, Masase Nagase1,3, Yasutoshi Jimbo1, Itsuro Saito1,3, Yusuke Inoue4, Tomoyuki Yambe4, Masaki Sekino1, George G. Malliaras5, Tomoyuki Yokota1, Masaru Tanaka2, Takao Someya1,6
1 Department of Electrical Engineering and Information Systems, The University of Tokyo
2 Institute for Materials Chemistry and Engineering, Kyushu University
3 iMed Japan Inc.
4 Department of Medical Engineering and Cardiology, Institute of Development Aging and Cancer, Tohoku University
5 Electrical Engineering Division, University of Cambridge
6 Thin-Film Device Laboratory & Center for Emergent Matter Science (CEMS)
High-precision monitoring of electrophysiological signals with high spatial and temporal resolutions is one of the most important subjects for elucidating physiology functions. Recently, ultraflexible multielectrode arrays (MEAs) have been fabricated to establish conformal contacts with the surface of organs and to measure propagation of electrophysiological signals with high spatial-temporal resolution; however, plastic substrates have high Young’s modulus, causing difficulties in creating appropriate stretchability and blood compatibility for applying them on the dynamically moving and surgical bleeding surface of the heart. Here, we have successfully fabricated an active MEA that simultaneously achieves nonthrombogenicity, stretchability, and stability, which allows long-term electrocardiographic (ECG) monitoring of the dynamically moving hearts of rats even with capillary bleeding. Because of the active data readout, the measured ECG signals exhibit a high signal-to-noise ratio of 52 dB. The novel stretchable MEA is carefully designed using state-of-the-art engineering techniques by combining extraordinarily high gain organic electrochemical transistors processed on microgrid substrates and a coating of poly(3-methoxypropyl acrylate), which exhibits significant antithrombotic properties while maintaining excellent ionic conductivity.
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